Electrophysiologic Characteristics of Epidural Spinal Signals in Preclinical Models of Spinal Cord Stimulation
This study outlines electrophysiologic signals evoked by SCS in terms of their waveform, recruitment thresholds, and putative physiologic origins. We propose that to some extent, these signals reflect different aspects of spinal processing and may serve as biomarkers of dysregulated nociceptive pathways, and as indicators of SCS efficacy or potential side effects.
Authors
- Quoc C. Vuong (ORCID: https://orcid.org/0000-0002-5983-964X)
- Mahima Sharma (ORCID: https://orcid.org/0000-0001-5482-6965)
- Eline Versantvoort
- Birte Dietz (ORCID: https://orcid.org/0000-0002-3533-7530)
- Stefano Palmisani (ORCID: https://orcid.org/0000-0001-9466-1704)
- Alexander Kraskov (ORCID: https://orcid.org/0000-0002-3576-4719)
- Stephen Baker (ORCID: https://orcid.org/0000-0001-6325-2254)
- Kimberley Ladner
- Marjolein E G Thijssen
- Ilona Obara
- Marom Bikson
- Dave Mugan
Institutions
- City College of New York (US)
- City University of New York (US)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Thomas Foundation (AU)
- Newcastle University (GB)
Publication Details
- Journal
- Neuromodulation Technology at the Neural Interface
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.neurom.2026.01.001
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Saluda Medical
- Newcastle University
- National Institutes of Health