Flt3L from interfollicular stroma maintains resident dendritic cells
Dendritic cell (DC) maintenance and positioning are essential for their function in lymph nodes. Wu et al. identify gremlin1 (Grem1)<sup>+</sup> fibroblastic reticular cells as critical source of niche-specific Fms-like tyrosine kinase 3 ligand (Flt3L) for conventional DC maintenance in health and disease, highlighting stromal cells as key regulators of immunity.
Authors
- Angela Riedel (ORCID: https://orcid.org/0009-0006-9411-4210)
- Arpa Aintablian
- Ayse N. Kilinc
Institutions
- University of Würzburg (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Trends in Immunology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.it.2026.01.010
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00