Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer
Cross-tissue single-cell atlas of tissue-resident macrophages (TRMs). Identification of conserved inflammatory TRM phenotype (iTRM) in pan-cancer. Dynamic convergence of TRM and monocyte-derived macrophage lineages. TRM inflammatory remodelling signature (TIR-Sig) with clinical potential.
Authors
- Peixin Zhu
- Baibing Guan
- Yuejiao Huang (ORCID: https://orcid.org/0000-0001-6532-9497)
- Jianhua Yin
- Zibin Chen
- Xinyue Zhu (ORCID: https://orcid.org/0000-0003-4900-1621)
- Jingzhi Lv
- Zhihao Hu
- Weikai Wang
- Yuhui Zheng
- Yin Zeng
- Chen Wei
- Zikun Ma
- Guibo Li
- Zhuoli Huang
- Xi Chen
- Yafei Yang
- Ziru Liao
- Xin Jin
- Xiao Yang
Institutions
- BGI Group (China) (CN)
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Shanxi Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Zhengzhou University (CN)
- Zhangzhou Municipal Hospital of Fujian Province (CN)
- Botswana Geoscience Institute (BW)
- Sun Yat-sen University Cancer Center (CN)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/ctm2.70608
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China
- Shenzhen Science and Technology Innovation Program