Low Toe-Brachial Indices are Associated with Saccular Intracranial Aneurysms
Low TBI was associated with a fourfold higher prevalence of unruptured IAs compared with normal TBI. In this retrospective cohort, the strongest association remained between low TBI and unruptured IAs after adjustment for established IA risk factors. These finding support a potential role of atherosclerosis in IA formation. Prospective studies are warranted to clarify the temporal relationship and to evaluate whether TBI could contribute to risk stratification in patients at risk of intracranial aneurysms.
Authors
- Harri Hakovirta
- Aino Kuusela
- D. Laukka
- Juri Kivelev (ORCID: https://orcid.org/0000-0002-5499-9628)
- E Kangas (ORCID: https://orcid.org/0000-0001-5505-1583)
- Päivi Korhonen (ORCID: https://orcid.org/0000-0002-5614-6442)
- Ville Rantasalo (ORCID: https://orcid.org/0000-0003-1385-2870)
- Melissa Rahi
- Rinne Jo
- M. Söderlund‐ Venermo
- Jussi Hirvonen
- Eelis Hakovirta
- Petra Korpisalo
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- Tampere University (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Kuopio University Hospital (FI)
- Tampere University (FI)
- University of Vaasa (FI)
Publication Details
- Journal
- Vascular Health and Risk Management
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/vhrm.s547932
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00