Transarterial chemoembolization (TACE) combined with immunotherapy and anti-angiogenic agents in intermediate-stage hepatocellular carcinoma (CHANCE2202): a target trial emulation study

National Natural Science Foundation of China (82130060, 82502493), China Postdoctoral Science Foundation (2025M772071), Jiangsu Provincial Basic Research ProgramNatural Science Foundation-Frontier Leading Technology Basic Research Project (BK20232008), Jiangsu Provincial Medical Innovation Center (CXZX202219), Postdoctoral Fellowship Program of CPSF (GZC20251385), and Natural Science Foundation of Jiangsu Province (BK20251687).

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Publication Details

Journal
EClinicalMedicine
Published
2026-02-01
DOI
https://doi.org/10.1016/j.eclinm.2026.103766
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
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article

Transarterial chemoembolization (TACE) combined with immunotherapy and anti-angiogenic agents in intermediate-stage hepatocellular carcinoma (CHANCE2202): a target trial emulation study

Weizhu Yang, Jianjian Chen, Duan Xu-Hua, Haidong Zhu et al.
EClinicalMedicine
Hepatocellular Carcinoma Treatment and Prognosis
article

Transarterial chemoembolization (TACE) combined with immunotherapy and anti-angiogenic agents in intermediate-stage hepatocellular carcinoma (CHANCE2202): a target trial emulation study

Weizhu Yang, Jianjian Chen, Duan Xu-Hua, Haidong Zhu, Guangshao Cao, Jinzhang Chen, Yujing Xin, Ai-Bing XU, Haibo Shao, Jun Tie, Zhenyu Dai, Jinwei Zhao, Zhi-Cheng JIN, Jiansong Ji, Fanpu Ji, Wen-Bin Ding, Hai-Bin Shi, Chuan-Sheng Zheng, Ming Huang, Qi Wang, Rong Ding, Ye-Ming Wu, Lan Zhang, Wen-Ge Xing, Zheng-Gang Ren, Jia-Wei Zhou, Xiao-Li Zhu, Yang Zhao, Gao-Jun Teng, Wei-Hua Zhang, Rui-Bao Liu, Jian-Bing Wu, Bin-Yan Zhong, Wei Zhao, Kang-Shun Zhu
article en

Abstract

National Natural Science Foundation of China (82130060, 82502493), China Postdoctoral Science Foundation (2025M772071), Jiangsu Provincial Basic Research ProgramNatural Science Foundation-Frontier Leading Technology Basic Research Project (BK20232008), Jiangsu Provincial Medical Innovation Center (CXZX202219), Postdoctoral Fellowship Program of CPSF (GZC20251385), and Natural Science Foundation of Jiangsu Province (BK20251687).

EClinicalMedicineVol. 92
Fujian Medical University (CN), Union Hospital (HK), Ministry of Education of the People's Republic of China (CN), Nanchang University (CN), Harbin Medical University (CN), Nantong University (CN), Fudan University (CN), Kunming Medical University (CN), Tianjin Medical University Cancer Institute and Hospital (CN), Lishui University (CN), Soochow University (CN), National Clinical Research Center for Digestive Diseases (CN), Second Affiliated Hospital of Guangzhou Medical University (CN), Zhejiang Cancer Hospital (CN), Nanfang Hospital (CN), Nantong Tumor Hospital (CN), Zhongda Hospital Southeast University (CN), Second Affiliated Hospital of Nanchang University (CN), Second People's Hospital of NanTong (CN), Shandong Provincial Hospital (CN), First Affiliated Hospital of Kunming Medical University (CN), Zhongshan Hospital (CN), Yancheng Third People's Hospital (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Henan Provincial People's Hospital (CN), First Hospital of China Medical University (CN), Zhengzhou People's Hospital (CN), Changzhou No.2 People's Hospital (CN), Jiangsu Province Hospital (CN), First Affiliated Hospital of Soochow University (CN), Chongqing Public Health Medical Center (CN), First Affiliated Hospital of Zhengzhou University (CN), Xijing Hospital (CN), Shandong First Medical University (CN), Union Hospital (CN), Hangzhou Cancer Hospital (CN), First Affiliated Hospital Zhejiang University (CN), Huazhong University of Science and Technology (CN), Southern Medical University (CN), Zhejiang University (CN), Nanjing Medical University (CN), Xi'an Jiaotong University (CN), Chongqing Medical University (CN), China Medical University (CN), Guangzhou Medical University (CN)
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Openalex Percentile: Top 62%
Hepatocellular Carcinoma Treatment and Prognosis
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