Deciphering Multitarget Mechanisms of Cardiac Glycosides in Acute Myeloid Leukemia Using a Network Pharmacology and Molecular Docking
Our findings elucidate multiple mechanisms by which CGs may exert anti-LSC activity, which could be crucial for the design of novel therapeutic strategies for AML. The proposed in silico framework is broadly applicable and may accelerate drug repurposing in AML and other cancers.
Authors
- Surapol Issaragrisil (ORCID: https://orcid.org/0000-0002-8924-0646)
- Jirarat Poohadsuan (ORCID: https://orcid.org/0000-0001-5528-5697)
- Supasorn Chanthateyanonth
- Parinya Samart
- Sudjit Luanpitpong
Institutions
- Siriraj Hospital (TH)
- Mahidol University (TH)
- Bangkok Hospital (TH)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/dddt.s561050
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00