A Case of Factor <scp>XIII</scp> Deficiency Identified by Recurrent Postoperative Bleeding After Tonsillectomy

Postoperative bleeding is a well-known complication of tonsillectomy. Although inadequate hemostasis and vascular injury are common causes, occult coagulation disorders may also contribute. Factor XIII deficiency is an extremely rare condition that is particularly difficult to detect preoperatively because PT and APTT typically remain normal. A 27-year-old man underwent bilateral tonsillectomy for a recurrent peritonsillar abscess. Despite normal coagulation screening, the patient developed repeated postoperative hemorrhages requiring surgical management. Further evaluation revealed reduced Factor XIII activity (36%). After Factor XIII concentrate administration, bleeding ceased, and the postoperative course stabilized. Factor XIII deficiency should be considered in patients with recurrent postoperative bleeding despite normal routine coagulation tests. Early recognition and timely replacement therapy may prevent severe complications.

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Publication Details

Journal
Clinical Case Reports
Published
2026-02-01
DOI
https://doi.org/10.1002/ccr3.72006
Primary Topic
Blood properties and coagulation
Type
article
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article

A Case of Factor XIII Deficiency Identified by Recurrent Postoperative Bleeding After Tonsillectomy

Takanobu Teramura, Akihiro Sakai, Hikaru Yamamoto, Koichiro Wasano et al.
Clinical Case Reports
Blood properties and coagulation
article

A Case of Factor XIII Deficiency Identified by Recurrent Postoperative Bleeding After Tonsillectomy

Takanobu Teramura, Akihiro Sakai, Hikaru Yamamoto, Koichiro Wasano, Masashi Hamada, Kenji Okami, Ai Yamamoto
article en

Abstract

Postoperative bleeding is a well-known complication of tonsillectomy. Although inadequate hemostasis and vascular injury are common causes, occult coagulation disorders may also contribute. Factor XIII deficiency is an extremely rare condition that is particularly difficult to detect preoperatively because PT and APTT typically remain normal. A 27-year-old man underwent bilateral tonsillectomy for a recurrent peritonsillar abscess. Despite normal coagulation screening, the patient developed repeated postoperative hemorrhages requiring surgical management. Further evaluation revealed reduced Factor XIII activity (36%). After Factor XIII concentrate administration, bleeding ceased, and the postoperative course stabilized. Factor XIII deficiency should be considered in patients with recurrent postoperative bleeding despite normal routine coagulation tests. Early recognition and timely replacement therapy may prevent severe complications.

Clinical Case ReportsVol. 14(2)
Tokai University (JP), Tokai University Hospital (JP)
Good health and well-being
Openalex Percentile: Top 65%
Blood properties and coagulation
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