Eupatolitin suppresses the invasion and migration of oral squamous cell carcinoma cells by regulating p38 mitogen-activated protein kinase signaling and downregulating cathepsin S/B expression

This study suggests that eupatolitin suppresses, at least partially, the migration and invasion of oral cancer cells by promoting p38 phosphorylation and downregulating cathepsin S and cathepsin B expression. The findings provide experimental evidence supporting the antimetastatic potential of eupatolitin. Nonetheless, further studies are required to confirm its translational relevance.

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Publication Details

Journal
European Journal of Pharmacology
Published
2026-02-01
DOI
https://doi.org/10.1016/j.ejphar.2026.178652
Primary Topic
Silymarin and Mushroom Poisoning
Type
article
Field-Weighted Citation Impact
0.00
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article

Eupatolitin suppresses the invasion and migration of oral squamous cell carcinoma cells by regulating p38 mitogen-activated protein kinase signaling and downregulating cathepsin S/B expression

Bharath Kumar Velmurugan, Yi-Ching Chuang, Hsin-Yu Ho, Yu-Sheng Lo et al.
European Journal of Pharmacology
Silymarin and Mushroom Poisoning
article

Eupatolitin suppresses the invasion and migration of oral squamous cell carcinoma cells by regulating p38 mitogen-activated protein kinase signaling and downregulating cathepsin S/B expression

Bharath Kumar Velmurugan, Yi-Ching Chuang, Hsin-Yu Ho, Yu-Sheng Lo, Min-Yun Kao, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
article en

Abstract

This study suggests that eupatolitin suppresses, at least partially, the migration and invasion of oral cancer cells by promoting p38 phosphorylation and downregulating cathepsin S and cathepsin B expression. The findings provide experimental evidence supporting the antimetastatic potential of eupatolitin. Nonetheless, further studies are required to confirm its translational relevance.

European Journal of PharmacologyVol. 1016
China Medical University (TW), Changhua Christian Hospital (TW), Council of Scientific and Industrial Research (IN)
Openalex Percentile: Top 65%
Silymarin and Mushroom Poisoning
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