Eupatolitin suppresses the invasion and migration of oral squamous cell carcinoma cells by regulating p38 mitogen-activated protein kinase signaling and downregulating cathepsin S/B expression
This study suggests that eupatolitin suppresses, at least partially, the migration and invasion of oral cancer cells by promoting p38 phosphorylation and downregulating cathepsin S and cathepsin B expression. The findings provide experimental evidence supporting the antimetastatic potential of eupatolitin. Nonetheless, further studies are required to confirm its translational relevance.
Authors
- Bharath Kumar Velmurugan (ORCID: https://orcid.org/0000-0002-4786-9913)
- Yi-Ching Chuang
- Hsin-Yu Ho
- Yu-Sheng Lo
- Min-Yun Kao
- Chia-Chieh Lin
- Ming-Ju Hsieh
- Mu-Kuan Chen
Institutions
- China Medical University (TW)
- Changhua Christian Hospital (TW)
- Council of Scientific and Industrial Research (IN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.ejphar.2026.178652
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00