Combined Maternal and Offspring Vitamin D3 Supplementation Ameliorates Autism-Like Behaviors via VDR Pathway Activation, Neuroinflammatory Suppression, and Metabolic Homeostasis Restoration
Combined maternal and offspring vitamin D3 supplementation significantly improves autism-like behaviors in a "dual-hit" ASD model. The observed protective effects may involve activation of the VDR pathway, reduction of neuroinflammation and neurotoxic metabolites, and systemic restoration of immune and metabolic homeostasis. These findings suggest the potential utility of vitamin D in ASD prevention and intervention, warranting further investigation.
Authors
- Jiang Xie
- Xing Wan
- Wenming Xu
- Mingyang Yuan
- Xiaohaoran Lyu
- Qingxi Li
- Jierui Yan
- Jing Zhang
- Yuting Yang
- Le Zou
Institutions
- Sichuan University (CN)
- Seventh People's Hospital of Shanghai (CN)
- Southwest Jiaotong University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/ijgm.s573081
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province