Colchicine Alleviates Non-Atherosclerotic Vascular Aging by Targeting Endothelial Dysfunction and Inflammatory Status
Chronic colchicine treatment preserves endothelial function and vascular elastin structure and reduces arterial stiffness in a DNA-damage-driven model of non-atherosclerotic vascular aging. These findings highlight colchicine's pleiotropic vascular benefits beyond anti-inflammation, supporting its potential repurposing for primary prevention in vascular aging and cardiovascular health or the development of colchicine-mimicking drugs with greater selectivity and improved safety profiles.
Authors
- Dirk Duncker
- Ehsan Ataei Ataabadi (ORCID: https://orcid.org/0000-0002-9797-3890)
- Martine de Boer (ORCID: https://orcid.org/0000-0003-3405-654X)
- Usha M. Musterd‐Bhaggoe
- A.H. Jan Danser (ORCID: https://orcid.org/0000-0002-5052-3585)
- Annika A. Jüttner (ORCID: https://orcid.org/0000-0001-8078-7453)
- Soroush Mohammadi Jouabadi (ORCID: https://orcid.org/0000-0002-5710-3057)
- Richard van Veghel (ORCID: https://orcid.org/0000-0002-2249-1002)
- Anton J.M. Roks (ORCID: https://orcid.org/0000-0001-7155-1756)
- Keivan Golshiri (ORCID: https://orcid.org/0000-0002-8879-3177)
- René R. P. de Vries
- Yoëlle Goos
- J H Cornel
- Willem Bax
- Antoinette MaassenVanDenBrink
- Youri Boon
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Northwest Hospital (US)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s538430
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00