Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates <scp>SIRT3</scp> and Attenuates Experimental Pulmonary Hypertension
Our findings underscore the role of sEH-P in the development and progression of PH, partly through its regulation of SIRT3 expression, cell proliferation, and apoptosis-related proteins. Targeting sEH-P emerges as a promising therapeutic strategy for PH.
Authors
- Hind Messaoudi
- M. Ottaviani
- Matthieu Leuillier
- C. Morisseau
- Felix F. Lillich (ORCID: https://orcid.org/0009-0009-8800-7584)
- Raphaël Thuillet (ORCID: https://orcid.org/0000-0002-1379-3797)
- Mustapha Kamel Chelgham
- Paul Mulder
- Ewgenij Proschak
- Séverine Ménoret (ORCID: https://orcid.org/0000-0002-9200-4927)
- Richard Vincent
- Ly Tu
- Jeremy Bellien
- Christophe Guignabert
- Déborah Groussard
- Lionel Nicol
- Marc Humbert
- Ignacio Anegon
Institutions
- Goethe University Frankfurt (DE)
- Centre National de la Recherche Scientifique (FR)
- Transgene (France) (FR)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Normandie Université (FR)
- Hypertension pulmonaire : physiopathologie et innovation thérapeutique (FR)
- Institut de Transplantation Urologie en Nephrologie (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Bicêtre Hospital (FR)
- Université de Rouen Normandie (FR)
- University of California, Davis (US)
- Nantes Université (FR)
Publication Details
- Journal
- Comprehensive physiology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cph4.70108
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 31.02
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Région Normandie
- European Regional Development Fund