Insights Into <scp>circRNA</scp> ‐Mediated Lipid Metabolism in Cancer Progression

Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non-coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been elucidated, there remains a dearth of knowledge regarding their involvement and regulatory mechanisms in lipid metabolism within the context of cancer. This article provides an overview of the regulatory roles and specific mechanisms of circRNAs in cancer lipid metabolism reprogramming. By elucidating these mechanisms, it enhances our comprehension of the metabolic rewiring driving tumour development and uncovers new avenues for targeted therapy.

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Publication Details

Journal
Journal of Cellular and Molecular Medicine
Published
2026-02-01
DOI
https://doi.org/10.1111/jcmm.71052
Primary Topic
Cancer, Lipids, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Insights Into circRNA ‐Mediated Lipid Metabolism in Cancer Progression

Chunyu Zhang, Zhiwei Miao, Jingjing Cao, Xiaoyu Wang et al.
Journal of Cellular and Molecular Medicine
Cancer, Lipids, and Metabolism
article

Insights Into circRNA ‐Mediated Lipid Metabolism in Cancer Progression

Chunyu Zhang, Zhiwei Miao, Jingjing Cao, Xiaoyu Wang, Tongguo Shi
article en

Abstract

Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non-coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been elucidated, there remains a dearth of knowledge regarding their involvement and regulatory mechanisms in lipid metabolism within the context of cancer. This article provides an overview of the regulatory roles and specific mechanisms of circRNAs in cancer lipid metabolism reprogramming. By elucidating these mechanisms, it enhances our comprehension of the metabolic rewiring driving tumour development and uncovers new avenues for targeted therapy.

Journal of Cellular and Molecular MedicineVol. 30(3)
Nanjing University of Chinese Medicine (CN), Soochow University (CN), Zhangjiagang First People's Hospital (CN), First Affiliated Hospital of Soochow University (CN)
Good health and well-being
Openalex Percentile: Top 65%
Cancer, Lipids, and Metabolism
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