MIF-CD74 signaling drives immune modulation in medulloblastoma
Our multifaceted approach identified key tumor-immune interactions in medulloblastoma. Among these, MIF-CD74 was validated as a targetable interaction, demonstrating the utility of our integrative approach for identifying novel therapeutic targets across multiple tumor types.
Authors
- Bethany Remeniuk (ORCID: https://orcid.org/0000-0003-1961-5163)
- Colin Kwok (ORCID: https://orcid.org/0000-0001-8312-7215)
- Carlos Custódia (ORCID: https://orcid.org/0000-0001-7089-7675)
- Olivier Ayrault (ORCID: https://orcid.org/0000-0002-7942-6674)
- Chantelle Bowers (ORCID: https://orcid.org/0009-0006-7765-5891)
- Anya Fletcher
- Sonia Morlando (ORCID: https://orcid.org/0000-0002-9010-1336)
- Olivier Saulnier (ORCID: https://orcid.org/0000-0003-4111-1017)
- Natalie Monteiro
- Barbara Martins Da Costa (ORCID: https://orcid.org/0000-0002-8993-6790)
- Alaide Morcavallo
- A. Delaidelli
- Laura Donovan (ORCID: https://orcid.org/0000-0001-5557-5539)
- Olumide Ogunbiyi (ORCID: https://orcid.org/0000-0001-5208-5526)
- Rebecca M. Hill (ORCID: https://orcid.org/0000-0001-8405-2219)
- Sumana Shrestha (ORCID: https://orcid.org/0000-0002-5368-0818)
- Stacey Richardson (ORCID: https://orcid.org/0000-0003-1841-6330)
- Zhen You (ORCID: https://orcid.org/0000-0002-0578-4823)
- Miao Liu (ORCID: https://orcid.org/0000-0003-2095-7769)
- Regan Barfoot
- Tony Jackson
- Darren Locke
- Courtney Himsworth (ORCID: https://orcid.org/0000-0002-4233-7512)
- Diego Chillón Pino
- Louis Chesler
- Poul H. Sorensen
- Sergi Castellano
- Yara Sanchez-Corrales
- Claudia C Faria
- Brandon Wade
- Freya Gordon
- L Frank Huang
- Thomas S Jacques
- Dean Thompson
- Rafael Roque
- Benjamin Draper
- Karen Barker
- Xu Guo
- Kevin Greenslade
- Jacob Torrejon Diaz
- Bei Hopkins
- Carlos Lorenzo Gido Nery
- John Anderson
Institutions
- Université Paris-Sud (FR)
- BC Cancer Agency (CA)
- Centre National de la Recherche Scientifique (FR)
- Mayo Clinic (US)
- University of Lisbon (PT)
- Institute of Cancer Research (GB)
- Inserm (FR)
- Baylor College of Medicine (US)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- Great Ormond Street Hospital (GB)
- Massachusetts General Hospital (US)
- Hospital Universitário de Santa Maria (BR)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Texas Children's Hospital (US)
- Hospital de Santa Maria (PT)
- Children's Cancer Center (US)
- Canadian Centre for Applied Research in Cancer Control (CA)
- Akoya Biosciences (United States) (US)
- University College London (GB)
- Instituto Gulbenkian de Ciência (PT)
- Newcastle University (GB)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1093/neuonc/noag020
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00