Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4‐Deficient

SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features. The application of the SMARCA4 immunohistochemical marker facilitates accurate identification. This study presents a rare case of SMARCA4-deficient pulmonary invasive mucinous adenocarcinoma with high-grade transformation.

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Publication Details

Journal
Pathology International
Published
2026-02-01
DOI
https://doi.org/10.1111/pin.70095
Primary Topic
Chromatin Remodeling and Cancer
Type
article
Field-Weighted Citation Impact
0.00
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article

Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4‐Deficient

Xiaomin Dai, Heng Zheng, Yingying Cui, Fengli Fu et al.
Pathology International
Chromatin Remodeling and Cancer
article

Progressive Development of Pulmonary Invasive Mucinous Adenocarcinoma With SMARCA4‐Deficient

Xiaomin Dai, Heng Zheng, Yingying Cui, Fengli Fu, Fang Peng
article en

Abstract

SMARCA4-deficient non-small cell lung cancer is characterized by highly aggressive clinical behavior, diverse tumor subtypes, and complex histological features. The application of the SMARCA4 immunohistochemical marker facilitates accurate identification. This study presents a rare case of SMARCA4-deficient pulmonary invasive mucinous adenocarcinoma with high-grade transformation.

Pathology InternationalVol. 76(2)
Ningbo No. 2 Hospital (CN), Zhejiang Hospital (CN), Hangzhou Hospital of Traditional Chinese Medicine (CN)
Good health and well-being
Openalex Percentile: Top 64%
Chromatin Remodeling and Cancer
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