Gender-specific impact of follow-up intervals on disease control in rheumatoid arthritis: a nationwide analysis of 15 835 Chinese patients

This large-scale study revealed gender-dimorphic patterns in RA progression and health-care engagement. Females tended to exhibit better treatment response, with a more pronounced interval-dependent disease control trend. No significant interval-gender interaction confirmed this was a descriptive trend, not a validated gender-specific difference. Our findings emphasize the need for strategies accounting for such gender-dimorphic trends to optimize care continuity and improve RA management.

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Publication Details

Journal
Lara D. Veeken
Published
2026-02-01
DOI
https://doi.org/10.1093/rheumatology/keag079
Primary Topic
Rheumatoid Arthritis Research and Therapies
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article
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article

Gender-specific impact of follow-up intervals on disease control in rheumatoid arthritis: a nationwide analysis of 15 835 Chinese patients

Xiaoyan Cai, Kuanting Wang, Xingfa Tao, Pingle Wang et al.
Lara D. Veeken
Rheumatoid Arthritis Research and Therapies
article

Gender-specific impact of follow-up intervals on disease control in rheumatoid arthritis: a nationwide analysis of 15 835 Chinese patients

Xiaoyan Cai, Kuanting Wang, Xingfa Tao, Pingle Wang, Xiaomei LI, Qun Zheng, Yanping Qi, Dongmei Zhou, GaiLian Zhang, Y. Wang, Qiang Shu, Xiaohong Lv, Lie Dai, Zhanyun Da, Yujuan Shen, Yufang Lou, Meipu Chen, Xia Yang, Guoliang Yao, Jiping Wu, Fengyan Sun, Y. K. Cheng, Shunfang Shi, Ling Lei, S Y Wang, Yeying Yang, Linchen Liu, Liangliang Gong, Yunxia Liu, X Liu, Ning Tie, Yi Dai, Tianli Ren, Dongmei Xiao, Liming Xu, Haiying Chen, Dongyu Chen, Jiasheng Ma, Xuan Xia, Carmela D. Tan, Yikun He, Liangchun Tang, Yingying Gao, Yifang Mei, ShouJun Wang, Linxiao Ma, L. Pan, Xuqiang Jia, Yinong Li, Lihuan Guo, Kejia Yu, Fengju Li, Chunxian Li, Kexia Chai, Zhanfeng Gong, Tieyan Hong, Huaxiang Wu, Mu Rq, Linna Pang, Huixia Xiong, Shifang Chen, Qiuling Ding, Mingshu Sun, Xiaodan Kong, Fang Wang, Ge Zhang, Lei Liu, Luyao Wang, Huiling Li, Yi Zhang, Xiaojing Zhang, Wenjie Zheng, Wenhong Cai, Shaojun Zhang, Huiqin Yang, Zhen Wu, Bao Li, Ruirui Wang, Haili Shen, Zhaohui Zheng, Yadong Zhou, Wenze Xiao, Xiaobei An, Zihua Wang, Fuhai Feng, Yin Su, Hongyan Xu, Yongji Li, Ping Fu, Jinyu Wu, Shuping Zhong, Yisha Li, Huang Jin-bai, Xiaoru Li, Zhengfang Zhang, Wenqian Song, Lixia Pang, Qunfeng Dai, Jie Bai, Juan Guo, Q. K. Wu, Hongjian Yuan, Yujin Ye, Shushan Zhao, Wei Gou, Yiling Qian, L G Geng, Yuxiu Zhou, Li Wu, Y Chen, Zhichun Liu, yuehong huo, Xianghua Guo, Minfang Yuan, Yaqin Zhu, Weinan Lai, Huifang Li, Yufeng Qing, Yanni Wang, Yingliang Wang, Xiaoyan Xu, Yasong Li, Yayu Li, LI Rao, Hua Ma, Xiuqin Ma, Lindi Jiang, Haojie Xu, Rui Wu, Lijun Wu, Liyun Zhang, Ru Li, Xinyao Zhou, Shengfei Li, Jinhui Fu, Shuhong Chi, Hongtao Guo, Shengdong Li, Yan Zhang, Xiaoru Xia, Ji Luo, Supin Li, Wufang Qi, Dinglei Su, Yang Zhang, Fang Ma, Yuan Gao, Xiaolian Liu, Xinfang Huang, Silu Wei, Shuang Gao, Shujuan Zhou, Yun Guo, Lijuan Gao, Yanping Zhao, Na Wu, Xinhua Zhang, Jiahui Zhao, Lijie Yu, Lin Pan, Haiyan Yu, Jiajia Wang, Bin Qiao, Xiaomin Liu, Li Zhao, Luyang Zhang, Binbin Wan, Yu Liu, Juan Li, Jingye Liao, Jingjun Wang, Yanxin Li, Li Wen, Jing Zhang, Qiaohong Wang, Shuang Liu, Na Wang, Rui Wu, Ying Huang, Yanling Wang, Xiaodong Zhu, Jian Wu, Yanfei Chen, Haisheng Zhang, Xin Lu, Yan Li, Tianrong Guan, Ying Guan, Jingyang Li, Ling Zheng, Li Li, Yun Zhao, Zhuo Deng, Jin Lin, Li Sun, Xuemei Yu, Gang Wang, Caihong Wang, Jin Ding, Lihua Li, Ling Li, Ning Yang, Ping Li, Ou Jin, Xiaoqi Chen, Wei Zhou, Xuehong Lu, Lijun Wu, Xinying Liu, Yingxue Wang, Hui Song, Ying Liu, Lin Liu, Jie Gao, Baimayangjin, Xiujie Song, Wei Zhang, Lijuan Zhu, Wen Zhang, Bin Jia, Wei Wei, Hui Zhao, Peirong Chen, Yuewu Lu, Wenqian Li, Baoyu Zhang, Xiaodong Wang, Tao Cheng, Fan Wu, Jie Shen, Jian Wang, Mei Tian, Jiaxuan Li, Yu Mei, Yuan Feng, Lihui Ma, Yuling Wang, Shuai Wang, Fang Li, Li Cui, Cuimin Guo, Yong Chen, Xia Dong, Qin Li, Jingping Hu, Jianhui Ma, Tong Liu, Zhichao Wang, Fan Wang, Liyun Zhang, Jinhua Yan, Pingting Yang, Hongyan Wen, Fuai Lu, Chunhua Shi, Bei Wang, Lianjie Shi, Zhe Liu, Wei Ji, Meimei Xu, Yunjing Bai, Haiyan Tong, Yi Yang, Linjie Chen, Xingguo Chen, Jiangyun Peng, Chunyan Chen, Li Wang, Hui Liu, Juan Du, Shan Huang, Minghua Xu, Yuhua Wang, Xianming Long, Danan Yang, Ming Gui, Qianwen Yang, Tao Yue, Jianyu Dai, Qingwen Wang, Wancang Yao, Yu Xue, Shuang Fu, Huiling Qian, Lina Wang, Yang Li, Jin Zhang, Guoqing Li, Jianmin Xie, Huifen Yang, Qiong Jiang, Nie Jin, Yuan Li, Shuyun Wen, Fengjin Xu, Hongwei Qiang, Guofeng Wang, Lifeng Ping, Li Qin, Lei Luo, Quan Jiang, Xiaoling Li, Lei Yang, Ling Lin, Yuxia Ma, Jing Wang, Qinghua Chang, Xiaofei Shi, Xiaoling Liu, Xuemei Tian, Jing Liu, Hua Wei, Yanying Liu, Jing Lu, Miaojia Zhang, Limei Gu, Tong Pan, Jun Sheng, Lingfei Guo, Yan Liu, Jing Yu, Fang Lv, Lihua Zhang, Baijie Xu, Shuyan Yang, Fen Li, Jianying Chen, Wei Liu, Hongli Sun, Feng Yue, Junhua Guo, Xuling Yang, Juan Chen, Jihua Wang, Yanchun Tang, Huiyuan Li, Sheng Chen, Yanqiu Wei, Pei Wang, Xiaohong Ji, Qing Zhao, Wenjia Sun, Ning Chen, Jia Fan, Zhen Zhang, Danqing Huang, Yuan Liu, Yan Wang, Yaping Luo, Min Wu, Yang Liu, Ling Zhao, Lin Zheng, Bo Lou, Lingli Dong, Menglin Zhao, Jing Yang, Yan Shen, Zhongming Yu, Jia Wang, Xiaolu Huang, Chunyan Zhang, Yingkun Nie, Conghui Sun, Rong Du, Feng Zhu, Bin Wang, Tingting Lv, Dandan Chen, Qian Wu, Jiangli Xia, Lijun Zhang, Yafei Pang, Ji Qi, Dengxiao Zhang, Dandan Li, Huifang Guo, Fei Gao, Jing Zhu, Li Liang, Xin Wang, Jinying Lin, Wei Hu, Chunying Liu, Hui Shi, Guomin Sun, Zhenying Li
article en

Abstract

This large-scale study revealed gender-dimorphic patterns in RA progression and health-care engagement. Females tended to exhibit better treatment response, with a more pronounced interval-dependent disease control trend. No significant interval-gender interaction confirmed this was a descriptive trend, not a validated gender-specific difference. Our findings emphasize the need for strategies accounting for such gender-dimorphic trends to optimize care continuity and improve RA management.

Lara D. VeekenVol. 65(2)
University of Science and Technology of China (CN), Nanchang University (CN), Peking University (CN), Sichuan University (CN), West China Hospital of Sichuan University (CN), First Affiliated Hospital of Jiangxi Medical College (CN), Nanjing Drum Tower Hospital (CN), People's Hospital of Xinjiang Uygur Autonomous Region (CN), Peking University People's Hospital (CN), First Affiliated Hospital of GuangXi Medical University (CN), Shanxi Academy of Medical Sciences (CN), First Affiliated Hospital of Nanchang University (CN), Shanxi Datong University (CN)
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