20-Year Experience With Decellularized Pulmonary Homografts for Pulmonary Valve Replacement
Decellularized pulmonary homografts show good long-term results for PVR with freedom from explantation that appears favourable compared with published long-term series of cryopreserved homografts. However, our data also indicate a decline in valve function over 2 decades. We hypothesize that residual immunogenicity is the underlying cause, suggesting that there is potential for further refinement of decellularization methods.
Authors
- Ciubotaru Anatol
- Samir Sarikouch (ORCID: https://orcid.org/0000-0001-7277-7597)
- Tudorache Igor
- Cebotari Serghei
- Beerbaum Philipp
- Westhoff-Bleck Mechthild
- Cazacu Anatolie
- Cheptanaru Eduard
- Boethig Dietmar
- Bobylev Dmitry
- Horke Alexander
- Avsar Murat
- Ruhparwar Arjang
- Cvitkovic Tomislav
Institutions
- Medizinische Hochschule Hannover (DE)
- Zurich Heart House (CH)
- Pharmaceutical Formulations (United States) (US)
- The Cardiac and Vascular Institute (US)
- DNA Diagnostic (Denmark) (DK)
- San Diego Cardiac Center (US)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1093/ejcts/ezag087
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00