Dysregulation of Transient Receptor Potential Cation Channels and Epithelial-to-Mesenchymal Transition-Related Genes in Fuchs Endothelial Corneal Dystrophy: A Bioinformatics Approach
Dysregulated TRP cation channels contribute to cellular senescence and peripheral sensitization in FECD, whereas altered apoptotic regulators drive corneal endothelial cell death. Most likely, these pathways represent potential targets for treatment of patients with FECD.
Authors
- Theofilos Tourtas (ORCID: https://orcid.org/0000-0002-3465-9837)
- Naoki Okumura (ORCID: https://orcid.org/0000-0003-2275-5263)
- Prema Padmanabhan (ORCID: https://orcid.org/0000-0001-7248-9907)
- Sailaja Elchuri (ORCID: https://orcid.org/0000-0002-9780-2717)
- Noriko Koizumi (ORCID: https://orcid.org/0000-0002-6940-1334)
- FE Kruse
- Taichi Yuasa
- Kiran Bharat Gaikwad
- Ursula Schlötzer-Schrehardt
- Harshavardhan Bv
- Janakiraman Narayanan
Institutions
- Sankara Nethralaya (IN)
- Doshisha University (JP)
- Manipal Academy of Higher Education (IN)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Institute of Bioinformatics (IN)
- Indian Institute of Science Bangalore (IN)
Publication Details
- Journal
- Cornea
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1097/ico.0000000000004099
- Primary Topic
- Connexins and lens biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00