Silent imposter in pneumonic attire: primary pulmonary MALT lymphoma

Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma confined to the lungs, accounting for <1% of non-Hodgkin lymphomas. We describe a man in his early 30s presenting with progressive dyspnoea, fever and productive cough, initially treated as pneumonia. Despite multiple antibiotic courses, radiological lesions persisted. Histopathology and immunohistochemistry from transbronchial lung biopsy revealed extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. PET-CT confirmed localised pulmonary involvement, fulfilling criteria for PPL. The patient responded to rituximab-bendamustine chemoimmunotherapy with clinical improvement. This case highlights the importance of considering rare malignancies in non-resolving pulmonary consolidations.

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Publication Details

Journal
BMJ Case Reports
Published
2026-02-01
DOI
https://doi.org/10.1136/bcr-2025-269557
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
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article

Silent imposter in pneumonic attire: primary pulmonary MALT lymphoma

Somesh Thakur, Krishnan E Namboothri, Jisha G Panicker, Javeeria Shabbir
BMJ Case Reports
Lymphoma Diagnosis and Treatment
article

Silent imposter in pneumonic attire: primary pulmonary MALT lymphoma

Somesh Thakur, Krishnan E Namboothri, Jisha G Panicker, Javeeria Shabbir
article en

Abstract

Primary pulmonary lymphoma (PPL) is a rare extranodal lymphoma confined to the lungs, accounting for <1% of non-Hodgkin lymphomas. We describe a man in his early 30s presenting with progressive dyspnoea, fever and productive cough, initially treated as pneumonia. Despite multiple antibiotic courses, radiological lesions persisted. Histopathology and immunohistochemistry from transbronchial lung biopsy revealed extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. PET-CT confirmed localised pulmonary involvement, fulfilling criteria for PPL. The patient responded to rituximab-bendamustine chemoimmunotherapy with clinical improvement. This case highlights the importance of considering rare malignancies in non-resolving pulmonary consolidations.

BMJ Case ReportsVol. 19(2)
All India Institute of Medical Sciences Raipur (IN), All India Institute of Medical Sciences Bhopal (IN), All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 65%
Lymphoma Diagnosis and Treatment
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