Immuno‐Packed T‐Cell‐Fusogenic Liposome Empowers Adoptive T Cell Therapy for Solid Tumor Treatment (Adv. Mater. 8/2026)

IMPACTFUL Adoptive T Cell Therapy In their Research Article (DOI: 10.1002/adma.202510842), Mingqiang Li, Yu Tao, Haochen Yao, and co-workers present an immuno-packed T-cell-fusogenic liposome (IMPACTFUL) that enables T-cell engineering through membrane fusion. This approach facilitates concurrent targeting across multiple cellular compartments, including the cell membrane and cytoplasm. By leveraging this dual-targeting strategy, T cells acquire enhanced functionalities, such as improved tumor infiltration, overcoming immune tolerance, and reversing the immunosuppressive tumor microenvironment. This versatile platform offers a promising approach to enhance the therapeutic efficacy of adoptive T cell therapies for solid tumors.