Management of essential thrombocythaemia-associated toe ulcer with a novel topical macrophage-modulating cream containing extract of <i>Plectranthus amboinicus</i>

A novel macrophage-modulating cream containing proprietary extracts from <i>Plectranthus amboinicus</i> and <i>Centella asiatica</i> has been approved for the treatment of diabetic ulcers in some countries. It has been reported to suppress M1 macrophages and facilitate the transition from M1 to M2 macrophages, reducing inflammation and leading to faster wound healing. Based on its mode of action, it has also been used in non-diabetic wounds. This report describes the treatment of a patient with essential thrombocythaemia (ET) presenting initially as a toe ulcer, and which was successfully managed with the cream before the use of systemic therapy for the ET.