Meconium metabolomic profiling dysregulation and neonatal brain injury in selective fetal growth restriction
Dysregulated fatty acid metabolites in the meconium of sFGR neonates are associated with severe brain injury. Divergent metabolomic profiles between sFGR-S and sFGR-L revealed distinct pathological mechanisms underlying brain injury. These findings provide novel insights into metabolic mechanisms of brain injury in sFGR and offer potential predictive biomarkers for adverse neurological outcomes.
Authors
- Hui Jiang (ORCID: https://orcid.org/0000-0002-1156-9046)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Yanrong Sun
- Xiya Sun
- Yixin Li
- Youzhen Zhang
- Nana Huang
- Yangyu Zhao
Institutions
- Peking University (CN)
- Beijing University of Technology (CN)
- Reproductive Science Center (US)
- National Institute of Quality (PE)
- Peking University Third Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s12884-026-08727-9
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Peking University
- Peking University Third Hospital
- National Key Research and Development Program of China