Reproductive lifespan and hormonal therapy in relation to later-life neurovascular health: A population-based study of women in the Gothenburg H70-1944 Birth Cohort
Extended estrogen exposure throughout life-both endogenous and exogenous-appear to support late-life cerebrovascular health in women, with potential genotype-specific neuroprotective effects. Given the current absence of sex-specific prevention guidelines for cognitive disorders, future research should clarify estrogen's longterm impact on brain health and cognition to inform personalized medicine.
Authors
- Giulia Lorenzon (ORCID: https://orcid.org/0009-0004-1562-9677)
- Stranges
- Gillian Coughlan (ORCID: https://orcid.org/0000-0003-1806-702X)
- Konstantinos Poulakis (ORCID: https://orcid.org/0000-0002-6600-8086)
- Anna Marseglia (ORCID: https://orcid.org/0000-0002-9672-6978)
- Lina Rydén (ORCID: https://orcid.org/0000-0002-3817-2620)
- Rosaleena Mohanty (ORCID: https://orcid.org/0000-0001-6499-1251)
- Gemma García-Lluch
- Jenna Najar
- Sara Shams
- Silvia Maioli
- Ingmar Skoog
- Silke Kern
- Eric Westman
Institutions
- Brigham and Women's Hospital (US)
- Karolinska University Hospital (SE)
- Harvard University (US)
- The University of Melbourne (AU)
- Universidad Cardenal Herrera CEU (ES)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Yale University (US)
- Massachusetts General Hospital (US)
- Stanford Health Care (US)
- Amsterdam Neuroscience (NL)
- Instituto de Investigación Sanitaria La Fe (ES)
- Imperial College London (GB)
- Australian Psychological Society (AU)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Stanford University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-05
- DOI
- https://doi.org/10.64898/2026.02.04.26345605
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00