Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Hereditary Transthyretin Amyloidosis Polyneuropathy
In ATTRv, zNfL correlates with neuropathy severity and symptomatic transition. A zNfL > 1.42 may discriminate symptomatic from asymptomatic subjects. zGFAP is not a reliable biomarker of polyneuropathy in ATTRv. Routine use of NfL should be based on deviation measure such as Z-score.
Authors
- Marie Théaudin
- Pansy Lim Dubois Ferriere
- Thierry Küntzer (ORCID: https://orcid.org/0000-0002-7788-1673)
- Alex Vicino (ORCID: https://orcid.org/0000-0001-6420-8124)
- Valentin Loser (ORCID: https://orcid.org/0000-0002-2609-6843)
- Jens Kuhle
- Pascal Benkert
- Chantal Daigneault
- Aleksandra Maleska Maceski
- Nicolas Ghika
Institutions
- University Hospital of Basel (CH)
- Department of Biomedicine Basel (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of the Peripheral Nervous System
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1111/jns.70104
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00