Outcomes following the discontinuation of biologic therapy in patients with severe asthma
Baseline eosinophilia, persistent sputum during therapy, and discontinuation prompted by poor response or cost may serve as risk factors for post-discontinuation exacerbations; however, risk is phenotype- and class-dependent. Careful patient selection and monitoring are essential when considering the discontinuation of biologic treatment.
Authors
- Kazuto MATSUNAGA
- Ryuta Haraguchi
- Tatsuya Nagano (ORCID: https://orcid.org/0000-0003-0790-5139)
- Toshiyuki Koya
- Noboru Hattori (ORCID: https://orcid.org/0000-0002-8234-942X)
- H. Sagara
- Kimiko Tsuji
- Yoichi Nakamura (ORCID: https://orcid.org/0000-0001-5958-5304)
- Hiroshi Matsumoto (ORCID: https://orcid.org/0000-0001-7842-504X)
- Takashi Hajiro
- Masayuki Hojo (ORCID: https://orcid.org/0000-0002-9595-9657)
- Hajime Fujimoto (ORCID: https://orcid.org/0000-0003-2440-9655)
- Yuji Tohda
- Hironobu Sunadome (ORCID: https://orcid.org/0000-0002-4617-2348)
- Hiroyuki Sano (ORCID: https://orcid.org/0000-0002-8581-4809)
- K Sekiya
- Masato Muraki (ORCID: https://orcid.org/0000-0002-7656-5206)
- Akihiko Tanaka
- Tomoya Harada
- Shogo Sakurai
- Akio Niimi
- Yuko Komase
- Takashi Iwanaga
- Kazuhisa Asai
- Nobuaki Miyahara
- Takeshi Kaneko
- Yasuhiro Gon
- Koichi Fukunaga
- Masafumi Yamaguchi
- Akiko Sano
- Norihiro Harada
Institutions
- Nihon University (JP)
- Hiroshima University (JP)
- SHOWA Medical University (JP)
- Shiga University of Medical Science (JP)
- Okayama University (JP)
- Osaka Ohtani University (JP)
- Yamaguchi University (JP)
- Mie University (JP)
- Keio University (JP)
- Kyoto University (JP)
- Tenri Hospital (JP)
- Nagoya City University (JP)
- Juntendo University (JP)
- National Center for Global Health and Medicine (JP)
- Yokohama City Seibu Hospital (JP)
- Nara Medical University Hospital (JP)
- National Sagamihara Hospital (JP)
- Shizuoka General Hospital (JP)
- Yokohama Municipal Minato Red Cross Hospital (JP)
- Osaka Metropolitan University (JP)
- Tottori University (JP)
- Kobe University (JP)
- Tokyo Metropolitan University (JP)
- Niigata University (JP)
- Kōchi University (JP)
- Yokohama City University (JP)
- Kindai University (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.alit.2025.12.004
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00