ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses

This study elucidated a previously unrecognized role of ENY2 in tumor growth, clarified the NPM1/MDM2/ p53-dependent mechanism of ENY2-mediated tumor cell growth suppression. We also provided a novel p53-independent RISC-IL11 nucleolar stress response pathway, which may provide a new target for the treatment of breast cancer.

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Publication Details

Journal
Cellular Oncology
Published
2026-02-05
DOI
https://doi.org/10.1007/s13402-025-01148-4
Primary Topic
Nuclear Structure and Function
Type
article
Field-Weighted Citation Impact
0.00
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article

ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses

唐宇姣, Yujiao Zou, Zhiqin Zhu, Yanjie Hou et al.
Cellular Oncology
Nuclear Structure and Function
article

ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses

唐宇姣, Yujiao Zou, Zhiqin Zhu, Yanjie Hou, He S, Shiqi Zuo, Ziqing Wu
article en

Abstract

This study elucidated a previously unrecognized role of ENY2 in tumor growth, clarified the NPM1/MDM2/ p53-dependent mechanism of ENY2-mediated tumor cell growth suppression. We also provided a novel p53-independent RISC-IL11 nucleolar stress response pathway, which may provide a new target for the treatment of breast cancer.

Cellular OncologyVol. 49(1)
Central South University (CN), Key Laboratory of Guangdong Province (CN), Zhujiang Hospital (CN), TCM-Intigrated Cancer Center of Southern Medical University (CN), Xiangya Hospital Central South University (CN), Southern Medical University (CN)
Openalex Percentile: Top 65%
Nuclear Structure and Function
DOIOpen Access PDFOpenAlex
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ENY2 transcription and export complex 2 subunit deficiency induces nucleolar stress to inhibit tumor progression through NPM1/MDM2/p53-dependent and -independent responses — 唐宇姣, Yujiao Zou, et al. · Cellular Oncology (2026) | TGRS Research Map | TGRS