Integrative omics analysis reveals distinct adaptations of bongkrekic acid producing Burkholderia gladioli pathovar cocovenenans strains

Genomic, transcriptomic, and metabolomic analyses show that the <i>bon</i> gene cluster is highly conserved in <i>Burkholderia gladioli</i> and predominantly clustered within specific branches of the phylogenetic tree. The presence of this gene cluster correlates with specific pathogenic traits and is associated with alterations in T3SS expression and metabolic characteristics, which are closely linked to bacterial adaptability across diverse ecological environments. The developed toxin-specific probes provide a reliable tool for rapid detection, supporting future monitoring and control efforts.