Enduring improvements in hepatic insulin sensitivity predict sustained remission of prediabetes during a 3-year lifestyle intervention: results from the PREVIEW multinational diabetes prevention trial
In a long-term lifestyle intervention, sustained remission of prediabetes was associated with enduring improvements in hepatic insulin sensitivity, regardless of weight change. In addition to weight loss, targeting hepatic insulin sensitivity per se may help prevent relapse in prediabetes.
Authors
- Marta P. Silvestre (ORCID: https://orcid.org/0000-0001-9327-2897)
- Nils Swindell (ORCID: https://orcid.org/0000-0003-3742-6139)
- Svetoslav Handjiev (ORCID: https://orcid.org/0000-0002-9717-7106)
- Ruixin Zhu (ORCID: https://orcid.org/0000-0003-2170-4667)
- Wolfgang Schlicht (ORCID: https://orcid.org/0000-0002-2134-2259)
- Gareth Stratton (ORCID: https://orcid.org/0000-0001-5618-0803)
- Maija Huttunen‐Lenz (ORCID: https://orcid.org/0000-0002-1034-1613)
- Teodora Handjieva‐Darlenska (ORCID: https://orcid.org/0000-0001-8307-343X)
- SD Poppitt
- Navas-Carretero Santiago
- Anne Raben
- Mikael Fogelholm
- Ian A. Macdonald
- J. Alfredo Martinez
- Jennie Brand-Miller
- Jie Guo
Institutions
- University of Stuttgart (DE)
- Madrid Institute for Advanced Studies (ES)
- University of Copenhagen (DK)
- The University of Sydney (AU)
- University of Helsinki (FI)
- University of Auckland (NZ)
- Medical University of Sofia (BG)
- Swansea University (GB)
- University of Design Schwäbisch Gmünd (DE)
- Navarre Institute of Health Research (ES)
- Centro de Investigación Biomédica en Red (ES)
- Queen's Medical Centre (GB)
- China Agricultural University (CN)
- Universidad Autónoma de Madrid (ES)
- Universidade Nova de Lisboa (PT)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Metabolism
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.metabol.2026.156546
- Citations
- 1
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 30.73
Funders
- Helsingin Yliopisto
- Suomen Lääketieteen Säätiö
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Glycemic Index Foundation
- National Institute for Health and Care Research
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Juho Vainion Säätiö
- Novo Nordisk
- Emil Aaltosen Säätiö
- Diabetestutkimussäätiö
- Directorate for Biological Sciences
- Medical Research Council
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council
- National Health and Medical Research Council
- Jenny ja Antti Wihurin Rahasto
- Wageningen University and Research