Possible role of pre-vaccination T-lymphocyte subpopulations in the antibody response to COVID-19 vaccines in children undergoing chemotherapy
Our study suggests that an adequate humoral immune response can be induced by the SARS-CoV-2 mRNA vaccine in pediatric oncology patients. We explored for the first time the possible association between pre-vaccination T lymphocyte subpopulations (CD3+CD56+, CD56+ NK, CD4+, CD4+CD3+CD56+ cells) and the antibody response to the COVID-19 vaccine. We have similar observations as previously reported with influenza vaccination, suggesting that CD3+CD56+ T cells may be involved in the immune response to SARS-CoV-2 vaccines. We highlight the connection between pre-vaccination CD4+ MAIT cell populations and the antibody response.
Authors
- L Tiszlavicz
- Ágnes Vojcek
- Zsolt István Komlósi (ORCID: https://orcid.org/0000-0002-4149-1497)
- Edit Ágota Brückner
- Bence Horváth (ORCID: https://orcid.org/0000-0002-8367-4259)
- Katalin Böröcz (ORCID: https://orcid.org/0000-0002-6126-1840)
- T. Berki
- Nikolett Jusztina Beniczky (ORCID: https://orcid.org/0000-0001-9650-0541)
- Noémi Benedek
- Krisztina Csanádi (ORCID: https://orcid.org/0009-0001-6277-0137)
- Zoltán Pós (ORCID: https://orcid.org/0000-0002-2574-7616)
- Daniel Janos Erdelyi (ORCID: https://orcid.org/0000-0001-5544-9209)
- Gábor Ottóffy (ORCID: https://orcid.org/0000-0002-8990-6620)
- Nikolett Lupsa
- S. Szabo (ORCID: https://orcid.org/0000-0003-3110-0699)
- Tímea Dergez (ORCID: https://orcid.org/0009-0003-1096-775X)
- Csaba Péterfia
- Nora Fekete
- Evelin A. Leibinger
- Péter Hauser
- Vita Vertike
Institutions
- Semmelweis University (HU)
- University of Miskolc (HU)
- University of Szeged (HU)
- Heim Pál Országos Gyermekgyógyászati Intézet (HU)
- Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház (HU)
- University of Pecs (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1728845
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00