Lunasin alleviates pulmonary inflammation in A549 alveolar epithelial cells and C57BL6/J mice in obese-mimicking conditions

In summary, <i>in vitro</i>, lunasin attenuated pro-inflammatory cytokines, possibly through enhancing SP-D expression and inhibiting NF-κB signaling in A549 cells. <i>In vivo</i>, dietary lunasin supplementation reduced pulmonary inflammation and modulated splenic cytokine balance. This study reveals for the first time that lunasin is a promising candidate for mitigating obesity-related pulmonary inflammation.