N‐Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis
The study findings suggest that NAC supplementation promoted greater preservation of bone quality, reduced periapical volume development, and modulation of endogenous antioxidant and oxidant aspects. This indicates that NAC can decrease local and systemic damage caused by AP, highlighting its potential as an adjunctive agent in processes involving systemic oxidative stress and the preservation of biological structures.
Authors
- Fabrício Aulo Ogliari (ORCID: https://orcid.org/0000-0002-2965-445X)
- Rafael Rodrigues Lima (ORCID: https://orcid.org/0000-0003-1486-4013)
- João Daniel Mendonça de Moura (ORCID: https://orcid.org/0000-0001-9845-9677)
- J. Ribeiro Cruz
- Renata Duarte de Souza‐Rodrigues (ORCID: https://orcid.org/0000-0002-1155-4768)
- Déborah Ribeiro Frazão (ORCID: https://orcid.org/0000-0001-9168-2606)
- Luciano Tavares Ângelo Cintra (ORCID: https://orcid.org/0000-0003-2348-7846)
- I. M. G. Santos (ORCID: https://orcid.org/0000-0002-3349-3994)
- Deiweson Souza‐Monteiro
- Zuleni Alexandre Lisboa da Silva
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto Federal de Educação, Ciência e Tecnologia do Pará (BR)
- Universidade Federal do Pará (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1111/iej.70108
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Ministério da Ciência, Tecnologia e Inovação
- Conselho Nacional de Desenvolvimento Científico e Tecnológico