IGF-1 as a mediator in the association between body mass index and risk of liver cancer: A prospective analysis of 432,203 participants from the UK biobank

IGF-1 substantially mediates the association between BMI and liver cancer risk, suggesting BMI-related IGF-1 reduction is a potential mechanistic pathway.

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Publication Details

Journal
Growth Hormone & IGF Research
Published
2026-02-05
DOI
https://doi.org/10.1016/j.ghir.2026.101684
Primary Topic
Growth Hormone and Insulin-like Growth Factors
Type
article
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0.00
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article

IGF-1 as a mediator in the association between body mass index and risk of liver cancer: A prospective analysis of 432,203 participants from the UK biobank

Zhixian Bao, Yuhua Chen, Jie Gao, Wenwen Yang et al.
Growth Hormone & IGF Research
Growth Hormone and Insulin-like Growth Factors
article

IGF-1 as a mediator in the association between body mass index and risk of liver cancer: A prospective analysis of 432,203 participants from the UK biobank

Zhixian Bao, Yuhua Chen, Jie Gao, Wenwen Yang, Rui Ji
article en

Abstract

IGF-1 substantially mediates the association between BMI and liver cancer risk, suggesting BMI-related IGF-1 reduction is a potential mechanistic pathway.

Growth Hormone & IGF ResearchVol. 84
First Hospital of Lanzhou University (CN), Lanzhou University (CN)
Good health and well-being
Openalex Percentile: Top 66%
Growth Hormone and Insulin-like Growth Factors
DOIOpen Access PDFOpenAlex
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IGF-1 as a mediator in the association between body mass index and risk of liver cancer: A prospective analysis of 432,203 participants from the UK biobank — Zhixian Bao, Yuhua Chen, et al. · Growth Hormone & IGF Research (2026) | TGRS Research Map | TGRS