Ononin combined with Lactobacillus paracasei alleviates DSS-induced ulcerative colitis by ferroptosis via inhibiting JAK2/STAT3 signaling pathway
The combination of Ononin and <i>Lactobacillus paracasei</i> effectively ameliorated DSS-induced colitis in mice. Its protective mechanism involves suppressing inflammation and oxidative stress, inhibiting ferroptosis (potentially through blocking the JAK2/STAT3 pathway), and enhancing intestinal barrier integrity. These findings provide a strong preclinical rationale for developing this combination as a potential therapeutic strategy for UC.
Authors
- Meng-Jie Kang
- Mei Huang (ORCID: https://orcid.org/0000-0003-0915-018X)
- Yongwei Li (ORCID: https://orcid.org/0000-0002-0047-6557)
- Pan-Pan Jiao
- Shuhan Zhang (ORCID: https://orcid.org/0000-0002-9441-6386)
- Lin-shan Luo
- Qian-qian Guo
- Feng Yang
- Liang-zhu Si
- Wei Zhang
- Ju-cai Song
- Lei Dong
- Yue-sheng Gong
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Zhengzhou City Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.bbrep.2026.102482
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00