Comparative Analysis of Matrix Metalloproteinase-1 in Completely Edentulous Diabetic and Nondiabetic Individuals and Its Correlation with Glycemic Control Markers

of pathogenic bacteria in the edentulous state live in periodontal pockets rather than infiltrating the periodontal tissue.The microbe can never be effectively eradicated by the immune system.Tissue IntroductIonAmong the world's most important and rapidly expanding chronic health issues are diabetes and its consequences.Approximately, 743 million individuals worldwide suffer from severe periodontitis, making it the sixth most common disease globally.Its overall prevalence is 10.8%.Diabetes and periodontitis have been shown to be correlated in both directions, which implies that poor glycemic management may have an impact on periodontitis and, in more severe cases, tooth loss. 1 Diabetes can triple the risk for severe periodontal disease, according to the studies conducted previously on periodontitis patients. 2Additionally, compared to individuals without diabetes, patients with diabetes are more likely to present with periodontitis when their blood glucose levels are elevated. 3Eventually, over a period of time, this results in extraction of all teeth affected with severe periodontitis, and the patient will become edentulous.As people age and live longer, the prevalence of edentulism rises.Since dentists must satisfy older denture wearers, prosthodontic problems are closely linked to this growth. 4he extent of remaining ridge resorption (RRR) determines the course of treatment for these patients.RRR is currently thought to have a complex etiology.The adaptive immune response is also necessary for local osseous remodeling. 4,5Bone resorption is linked to cytokines, which are released by some lymphocytes.The majority