Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography
The determination of pH differences by glycosylamines radiotracers and PET imaging in acidic TME may serve as a novel marker for various questions such as interaction of pH regulation and response to immunotherapies. Notably, even small pH differences in the acidic TME of different tumors, in the same in vivo model, could be discriminated.
Authors
- Benedikt Klasen (ORCID: https://orcid.org/0000-0002-4433-0269)
- Dominik Schauenburg (ORCID: https://orcid.org/0009-0005-0662-5831)
- Tobias Bopp
- M. Schreckenberger
- Jürgen Brück
- Seah Ling Kuan (ORCID: https://orcid.org/0000-0003-3945-4491)
- Tanja Weil
- Lisa Schake
- Tozka Bohn
- Veronika Frommberger
- Kazem Ebadi Jalal
- Nabil Boui
- Aron Kwiatkowski
- Simeon Göttert
Institutions
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Maastricht University (NL)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Max Planck Institute for Polymer Research (DE)
- National Center for Tumor Diseases (DE)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s13550-026-01383-2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00