Clinical and Behavioral Outcomes During 4 Weeks of Home-Based Self-Administered Transcranial Direct Current Stimulation in Perinatal Women With Depressive Symptoms: Open-Label Exploratory Pilot Study

Results showed that 4 weeks of home-based, self-administered tDCS are feasible, well tolerated, and associated with improvements in depressive symptoms and objective behavioral activity among perinatal women. Self-reported symptom changes show stronger correlations with behavioral outcomes compared to clinician-rated scores. Although the lack of a control group precludes causal inference, these findings support the feasibility of integrating wearable monitoring with tDCS protocols and warrant further validation in randomized sham-controlled trials.