Stromal Vascular Fraction and Plasma-Jet: A Synergistic Approach to Enhance Acne Scar Treatment Outcomes

Background: Acne scars represent a significant dermatological concern, manifesting as marks and indentations on the skin surface following severe or prolonged acne. Both Plasma-Jet and Stromal Vascular Fraction (SVF) have been used in a synergistic approach to treat moderate to very severe types of acne scars. Objectives: The aim of this study is to evaluate the efficacy and safety of combining SVF and Plasma-Jet in the management of acne scars. Materials and Methods: This prospective single-arm clinical trial was conducted from September 2024 to September 2025 at Rizgary Teaching Hospital and Zheen International Hospital in Erbil, Iraq. Twenty patients aged 20–45 with moderate to very severe facial acne scars were treated with SVF and Plasma-Jet. The scar severity, improvement, and satisfaction were the outcomes of the study. Results: The mean age of the patients was 31.4 years (SD: 6.52, range: 20–45 years), predominantly male (80%). Most scars were bilateral cheek lesions (90%), classified as type II (55%), III (20%), or IV (25%), with moderate severity being the most common (55%). The baseline mean Goodman and Baron score was 16.1, significantly reduced to 8.05 post-treatment (p < 0.0001). Patient satisfaction was high, with 85% satisfied (50% very satisfied, 25% satisfied, and 10% satisfied but wanting more sessions), while 15% were not satisfied. All patients showed improvement: 50% significant, 35% moderate, and 15% mild. Improvement was consistent across age, gender, Fitzpatrick skin type, and initial severity (p > 0.05 for all), indicating the treatment’s effectiveness regardless of demographic or clinical factors. The combination therapy demonstrates promising results for diverse acne scar types and severities. Conclusion: Combined SVF and plasma-Jet treatment significantly improves acne scars, with high patient satisfaction and consistent results across age, gender, skin type, and severity, demonstrating safe and effective outcomes for diverse scar types.