Temporal dynamics of white matter hyperintensities related to Alzheimer's disease in adults with Down syndrome
WMH trajectories were heterogeneous in DS and declined over time with AD symptoms. This unexpected reduction may reflect different underlying pathological processes, including neurodegeneration or neuroinflammation.
Authors
- Lucía Pertierra
- Lucía Maure‐Blesa
- Isabel Barroeta (ORCID: https://orcid.org/0000-0003-2764-7923)
- María Carmona‐Iragui (ORCID: https://orcid.org/0000-0001-6914-2339)
- José Enrique Arriola‐Infante (ORCID: https://orcid.org/0000-0002-3298-4601)
- Olivia Belbin
- Sandra M. Giménez
- Mateus Rozalem‐Aranha
- Javier Arranz (ORCID: https://orcid.org/0000-0003-0891-1215)
- Juan M. Fortea (ORCID: https://orcid.org/0000-0002-1340-638X)
- María Franquesa‐Mullerat (ORCID: https://orcid.org/0009-0006-1484-7132)
- Zili Zhao
- Jose Allende Parra
- Lídia Vaqué‐Alcázar
- Laura Videla
- Sara E. Zsadanyi
- Íñigo Rodríguez‐Baz
- Bessy Benejam
- Susana Fernández
- Alberto Lleó
- Laura Del Hoyo Soriano
- Alejandra O. Morcillo‐Nieto
Institutions
- Universitat Autònoma de Barcelona (ES)
- Neurosciences Institute (US)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Instituto de Neurología Cognitiva (AR)
- Complejo Hospitalario Torrecárdenas (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71157
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00