Integrative Omics Analysis Reveals the Potential Value of CEACAM6 in Pan‐Gastrointestinal Cancers
CEACAM6 exhibits high diagnostic accuracy and tumor-specific overexpression in pan-gastrointestinal cancers. CEACAM6 could promote angiogenesis/metastasis and suppress anti-tumor immunity. Spatially localized in tumors with immune cell exclusion, CEACAM6 correlates with poor survival and immune-excluded subtypes, positioning it as a therapeutic target in precision immunotherapy for pan-gastrointestinal cancers.
Authors
- Peng Zhang
- Changjuan Tao
- Zhiyong Pan
- Liying Jin
Institutions
- Nantong University (CN)
- Zhejiang Cancer Hospital (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Yueyang Second People's Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/iid3.70327
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province
- Science and Technology Program of Zhejiang Province