A rapid review and narrative synthesis of the evidence for oral sodium chloride supplements in the management of heart failure
For patients with HF treated with loop diuretics, higher oral NaCl intake may increase serum and urine sodium concentration, improve renal function, and reduce neurohormonal activation. There is insufficient evidence to support oral NaCl as an adjunct to diuretic treatment. More research is needed.
Authors
- Andrea Hilton (ORCID: https://orcid.org/0000-0001-7264-0857)
- Maureen Twiddy (ORCID: https://orcid.org/0000-0002-3794-1598)
- Lee Middleton (ORCID: https://orcid.org/0000-0003-4621-1922)
- Sarah Greenley (ORCID: https://orcid.org/0000-0002-3788-6437)
- Laurence Humphries-Davies
- Thirimon Moe-Byrne
- M J Johnson
- O Amin
- John G. F. Cleland
Institutions
- Castle Hill Hospital (GB)
- Living Streets (GB)
- Hull York Medical School (GB)
- University of Glasgow (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1093/ehjopen/oeag017
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00