Astragaloside IV prevents calpain-1-mediated cardiac hypertrophy and fibrosis induced by diabetes
AsIV could ameliorate intracellular Ca<sup>2+</sup> overload, apoptosis, and oxidative stress by regulating the calpain-1/CaMKII pathway, thereby improving myocardial hypertrophy and fibrosis caused by diabetes mellitus.
Authors
- silin wei
- Meili Lu
- Ning Zhao
- Kangyin Chen
Institutions
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fcvm.2026.1670472
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Liaoning Province