<scp>WDR63</scp> Promotes Pulmonary Fibrosis Through Facilitating <scp>K63</scp> ‐Linked Ubiquitination of p53
WDR63 stabilises p53 through K63-linked polyubiquitination, thereby driving pathological changes in AECs and lung fibroblasts and aggravating pulmonary fibrosis. These findings demonstrate that targeting WDR63 represents a novel therapeutic strategy for IPF.
Authors
- Yuexia Yang
- L. Wang
- M. Ye
- Xin Pan (ORCID: https://orcid.org/0000-0003-1437-2780)
- Yajun Li (ORCID: https://orcid.org/0000-0001-8925-9999)
- Mengyuan Peng
- Zhongzheng Li
- Qiwen Wang
- Hongzhi Wen
- Feifan Shi
- Yingjie Wang
- Yue Zhang
- Guoying Yu
Institutions
- Henan Normal University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Respirology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1002/resp.70195
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00