Cognitive impairment in SCA3: A multi-center cohort study with demographic, imaging, and biomarker correlates
Cognitive deficits in SCA3 generally appear after clinical ataxia onset and progress in parallel with ataxia severity, especially in patients with a lower cognitive reserve. Other measured biochemical and imaging parameters did not have a significant additional contribution.
Authors
- M. João Lima
- Magda Magnolia Santana
- Roderick P.P.W.M. Maas (ORCID: https://orcid.org/0000-0003-0823-1287)
- Reetz Kathrin
- Heike Jacobi
- Luís Pereira de Almeida
- Carlos Eduardo Fortes Gonzalez
- Paola Giunti
- Bart P.C. van de Warrenburg
- Jon Infante
- Ludger Schöls
- Jeroen J. de Vries
- Chiadi U. Onyike
- Hector Garcia-Moreno
- Thomas Klockgether
- Jennifer Faber
- Friedrich Erdlenbruch
Institutions
- University of Minnesota (US)
- Universidad de Cantabria (ES)
- University Medical Center Groningen (NL)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- Universidade do Porto (PT)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- Johns Hopkins Medicine (US)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Radboud Institute for Molecular Life Sciences (NL)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital do Divino Espírito Santo (PT)
- Essen University Hospital (DE)
- Jülich Aachen Research Alliance (DE)
- University of Minnesota Medical Center (US)
- Hertie Institute for Clinical Brain Research (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Duisburg-Essen (DE)
- University of Coimbra (PT)
- University of Tübingen (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.nbd.2026.107301
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Friedreich's Ataxia Research Alliance
- National Ataxia Foundation
- Bristol-Myers Squibb
- Eli Lilly and Company
- Sanofi
- Biogen
- Fundo Regional para a Ciência e Tecnologia
- EU Joint Programme – Neurodegenerative Disease Research
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research
- Ataxia UK
- University College London
- European Commission
- Deutsche Forschungsgemeinschaft
- ZonMw
- Bundesministerium für Bildung und Forschung
- Eisai
- RWTH Aachen University
- Hersenstichting
- Servier
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- Medical Research Council
- Fundação para a Ciência e a Tecnologia