Surgical removal of Waldeyer’s ring and long-term risk of Sjögren’s syndrome: a population-based cohort study investigating the mucosal immune link

Tonsillectomy is independently associated with an increased risk of SS. These findings suggest that early-life removal of nasopharyngeal lymphoid tissue may disrupt the MALT axis, impairing oral tolerance and predisposing to salivary autoimmunity.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-05
DOI
https://doi.org/10.3389/fimmu.2026.1760386
Primary Topic
Salivary Gland Disorders and Functions
Type
article
Field-Weighted Citation Impact
0.00

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article

Surgical removal of Waldeyer’s ring and long-term risk of Sjögren’s syndrome: a population-based cohort study investigating the mucosal immune link

Jeng-Wen Peter Chen, Chia-Hung Su, Y H Wang, Chun-Hou Liao et al.
Frontiers in Immunology
Salivary Gland Disorders and Functions
article

Surgical removal of Waldeyer’s ring and long-term risk of Sjögren’s syndrome: a population-based cohort study investigating the mucosal immune link

Jeng-Wen Peter Chen, Chia-Hung Su, Y H Wang, Chun-Hou Liao, Hua-Wei Chi, Mingchih Chen, James Cheng-Chung Wei
article en

Abstract

Tonsillectomy is independently associated with an increased risk of SS. These findings suggest that early-life removal of nasopharyngeal lymphoid tissue may disrupt the MALT axis, impairing oral tolerance and predisposing to salivary autoimmunity.

Frontiers in ImmunologyVol. 17
Fu Jen Catholic University (TW), Chung Shan Medical University Hospital (TW), National Taiwan University Hospital (TW), Cardinal Tien Hospital (TW), Chung Shan Medical University (TW), China Medical University (CN)
Cardinal Tien Hospital, National Science and Technology Council
Good health and well-being
Openalex Percentile: Top 63%
Salivary Gland Disorders and Functions
DOIOpen Access PDFOpenAlex
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Surgical removal of Waldeyer’s ring and long-term risk of Sjögren’s syndrome: a population-based cohort study investigating the mucosal immune link — Jeng-Wen Peter Chen, Chia-Hung Su, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS