Small extracellular vesicle-mediated adipocyte-cardiomyocyte crosstalk exacerbates heart failure with preserved ejection fraction
The present work unveils a mechanism whereby obesity promotes HFpEF progression, emphasizing the role of VAT-heart crosstalk. Specifically, VAT-derived sEVs, miR-295-3p, and the resultant disruption of cardiac autophagy contribute significantly to the pathogenesis of HFpEF.
Authors
- Yao Jiang (ORCID: https://orcid.org/0000-0002-4934-0941)
- Gabriele G. Schiattarella (ORCID: https://orcid.org/0000-0002-7582-7171)
- Thomas G. Gillette (ORCID: https://orcid.org/0000-0002-7617-3544)
- GuiHao Chen
- Ce Zhang (ORCID: https://orcid.org/0000-0003-0574-8141)
- Qi Pan (ORCID: https://orcid.org/0000-0003-0134-0958)
- Han Zhang
- Cheng Chen
- Guixin Wu
- Ziqin Zhou
- Yuejin Yang
- Joseph A Hill
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Max Delbrück Center (DE)
- Deutsches Herzzentrum der Charité (DE)
- Federico II University Hospital (IT)
- German Centre for Cardiovascular Research (DE)
- Guangdong Academy of Medical Sciences (CN)
- Fu Wai Hospital (CN)
- Charité - Universitätsmedizin Berlin (DE)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1093/cvr/cvag030
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00