The effect of gender-affirming hormonal treatment on personality traits - a NEO-PI-R study
Few changes in personality traits were observed, but they aligned with expectations based on established sex differences in personality traits. In general, more changes were observed in the testosterone treated group. The reduction in "Neuroticism" and "Vulnerability" in the AFAB with treatment, but a worsening or no change in the AMAB may be concerning. Further studies are needed to solidify these results and explore the underlying causes.
Authors
- Mats Holmberg (ORCID: https://orcid.org/0000-0003-2884-9981)
- Ivanka Savic (ORCID: https://orcid.org/0000-0003-4275-0689)
- Alex Wallen
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Los Angeles Medical Center (US)
- Integrated Cardio Metabolic Centre (SE)
Publication Details
- Journal
- Comprehensive Psychoneuroendocrinology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.cpnec.2026.100338
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00