Indole‐3‐Acetic Acid Attenuates Metabolic‐Associated Steatohepatitis via <scp>APC</scp> to Inhibit β‐Catenin/Wnt Pathway
IAA acts as an antagonist of β-catenin/Wnt pathway via promoting APC expression and inhibiting β-catenin nucleus translocation. Consequently, IAA mitigates MASH-associated liver fibrosis by inhibiting HSCs activation and proliferation.
Authors
- Liang Dong (ORCID: https://orcid.org/0000-0002-1768-4264)
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Yue‐Ying Chen
- Jia Chen
- Da Zhou
- Jing‐Yi Si
- Fu‐Lin Nian
- Guang‐Cong Zhang
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Liver International
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1111/liv.70527
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00