Circadian gene expression in adolescents: Associations with concurrent circadian disruption and subsequent changes in cardiometabolic risk measures

Expression of core clock genes was linked to circadian disruption and changes in cardiometabolic risk factors in a sex-specific manner among adolescents. Our findings provide novel insights into potential biological mechanisms underlying associations of circadian disruption with cardiometabolic health.

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Publication Details

Journal
Sleep Medicine
Published
2026-02-05
DOI
https://doi.org/10.1016/j.sleep.2026.108819
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
0.00
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article

Circadian gene expression in adolescents: Associations with concurrent circadian disruption and subsequent changes in cardiometabolic risk measures

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Circadian rhythm and melatonin
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Circadian gene expression in adolescents: Associations with concurrent circadian disruption and subsequent changes in cardiometabolic risk measures

Helen J. Burgess, Ronald D. Chervin, Donghan Su, Erica C. Jansen, Louise M. O’Brien, Dana C. Dolinoy, Alejandra J Cantoral, Maricruz Tolentino, Libni Avib Torres-Olascoaga, Martha María Tellez-Rojo, Jennifer T. Lee, Karen E. Peterson, Peter X.K. Song, Jaclyn M. Goodrich
article en

Abstract

Expression of core clock genes was linked to circadian disruption and changes in cardiometabolic risk factors in a sex-specific manner among adolescents. Our findings provide novel insights into potential biological mechanisms underlying associations of circadian disruption with cardiometabolic health.

Sleep MedicineVol. 141
Universidad Iberoamericana (MX), University of Michigan (US), Instituto Nacional de Perinatología (MX), Michigan Medicine (US), Instituto Nacional de Salud Pública (MX)
Good health and well-being
Openalex Percentile: Top 61%
Circadian rhythm and melatonin
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