ANKRD53 is downregulated in human obesity and coordinates lipolysis with mitochondrial oxidative metabolism in adipocytes
ANKRD53 is reduced in obesity and coordinates lipolysis with mitochondrial oxidative metabolism in human adipocytes, promoting efficient use of lipolysis-derived FFAs via ACSL1. These findings establish ANKRD53 as a key regulator of adipocyte energy metabolism and a potential therapeutic target for improving metabolic health in obesity.
Authors
- T L Liu
- Yafen Ye
- Xiaoya Li (ORCID: https://orcid.org/0000-0002-6098-2195)
- Yingying Su (ORCID: https://orcid.org/0000-0002-0537-1551)
- Jinghao Cai
- Xuhong Lu
- Xiaojing Ma (ORCID: https://orcid.org/0000-0003-3043-1840)
- Yuting Yang (ORCID: https://orcid.org/0000-0001-6859-6195)
- Jingjing Sun
- Jian Zhou
- Yikai Wang
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.molmet.2026.102330
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00