IFNγ shapes macrophage inflammatory responses by STAT1 isoform-specific epigenetic and transcriptional mechanisms
Our findings uncover isoform-specific roles of STAT1 in IFNγ-driven epigenetic regulation and macrophage conditioning, providing new insights into the control of inflammation and innate immunity.
Authors
- Mathias Müller (ORCID: https://orcid.org/0000-0002-7879-3552)
- Florian Halbritter (ORCID: https://orcid.org/0000-0003-2452-4784)
- Birgit Strobl (ORCID: https://orcid.org/0000-0001-5716-3212)
- David Martin (ORCID: https://orcid.org/0000-0001-5783-7141)
- Claus Vogl (ORCID: https://orcid.org/0000-0002-3996-7863)
- Katrin Meissl (ORCID: https://orcid.org/0000-0003-2731-6657)
- Thomas Decker (ORCID: https://orcid.org/0000-0001-9683-0620)
- Lena Amenitsch (ORCID: https://orcid.org/0000-0003-4873-1155)
- Grigorios Georgolopoulos (ORCID: https://orcid.org/0000-0002-9906-4797)
- Nikolaus Fortelny (ORCID: https://orcid.org/0000-0003-4025-9968)
- Mojoyinola Joanna Akagha (ORCID: https://orcid.org/0000-0002-9940-232X)
- Matthias Farlik
Institutions
- University of Veterinary Medicine Vienna (AT)
- Tampere University of Applied Sciences (FI)
- University of Salzburg (AT)
- Max Perutz Labs (AT)
- Cancer Research Institute of the Slovak Academy of Sciences (SK)
- Community College of Rhode Island (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- BMC Genomics
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s12864-026-12601-5
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund