Lactylation-related gene signature as a prognostic biomarker for neuroblastoma: insights into tumor progression and immune modulation
Our findings establish lactylation as a critical determinant of neuroblastoma progression and prognosis. The seven-gene lactylation-related prognostic model provides a novel tool for patient stratification and therapeutic decision-making. Additionally, KLHL32 represents a promising target for enhancing immunotherapy efficacy by modulating metabolic and immune pathways, offering new opportunities for precision treatment in high-risk neuroblastoma patients.
Authors
- Jiefeng Yang
- Guannan Shu (ORCID: https://orcid.org/0000-0003-4075-3181)
- Muyang Luo
- Qiong Deng
- Guochang Liu (ORCID: https://orcid.org/0000-0002-7445-8394)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Meiyu Jin
- Li Yuan
- Jing He
- Zhu Wang
- Hui Liang
- Wen Fu
- Jiangquan Zhu
Institutions
- Sun Yat-sen University (CN)
- Longgang Central Hospital (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- ShenZhen People’s Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s13578-026-01538-7
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation